POLE3 and DRAP1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLE3	DRAP1
Description		DNA polymerase epsilon 3, accessory subunit	DR1 associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex CHRAC	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	DNA Replication Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Signaling by NODAL Signaling by Activin
Drugs		Cladribine
Diseases
GWAS			Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		14 interacting genes: ALAD APP ASTN2 BAZ1A CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32	31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1
Entrez ID		54107	10589
HPRD ID		06274	03796
Ensembl ID		ENSG00000148229	ENSG00000175550
Uniprot IDs		A0A024R829 Q9NRF9	Q14919
PDB IDs			1JFI
Enriched GO Terms of Interacting Partners?
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