POLE3

Description		DNA polymerase epsilon 3, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	DNA Replication Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS
Interacting Genes		14 interacting genes: ALAD APP ASTN2 BAZ1A CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32
Entrez ID		54107
HPRD ID		06274
Ensembl ID		ENSG00000148229
Uniprot IDs		A0A024R829 Q9NRF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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