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POLE4

Description DNA polymerase epsilon 4, accessory subunit
Image No pdb structure
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Epsilon DNA Polymerase Complex
Molecular Function
  • DNA Binding
  • DNA-directed DNA Polymerase Activity
  • Protein Binding
  • Protein Heterodimerization Activity
Biological Process
  • DNA Biosynthetic Process
Pathways
  • Recognition of DNA damage by PCNA-containing replication complex
  • PCNA-Dependent Long Patch Base Excision Repair
  • Termination of translesion DNA synthesis
  • HDR through Homologous Recombination (HRR)
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • DNA replication initiation
  • Activation of the pre-replicative complex
Drugs
  • Cladribine
Diseases
GWAS
  • Venous thromboembolism ( 33592630)
Interacting Genes 11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A
Entrez ID 56655
HPRD ID 16238
Ensembl ID ENSG00000115350
Uniprot IDs Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025