SERPINA4 and MAP4K2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SERPINA4	MAP4K2
Description		serpin family A member 4	mitogen-activated protein kinase kinase kinase kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome	Golgi Membrane Basolateral Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade
Pathways		Platelet degranulation
Drugs		Zinc Copper Zinc acetate	Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)	Serum uric acid levels ( 32514006) Urate levels ( 21768215)
Interacting Genes		14 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 TRIP11 YAE1	14 interacting genes: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A RELA SERPINA4 SNRNP35 TRAF2 XRCC6
Entrez ID		5267	5871
HPRD ID		01004	04408
Ensembl ID		ENSG00000100665	ENSG00000168067
Uniprot IDs		A0A024R6I9 P29622	A0A024R567 Q12851
PDB IDs		6F02
Enriched GO Terms of Interacting Partners?
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