MAP4K2 and DEFB1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		MAP4K2	DEFB1
Description		mitogen-activated protein kinase kinase kinase kinase 2	defensin beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Golgi Lumen Extrinsic Component Of Membrane Extracellular Exosome Sperm Midpiece Microvesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity	Protein Binding CCR6 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade	Innate Immune Response In Mucosa Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response CAMP-mediated Signaling Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways			Beta defensins Defensins
Drugs		Fostamatinib
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)	Blood pressure ( 24954895) Blood protein levels ( 30072576 29875488) Dental caries (decayed and filled deciduous teeth) ( 31533690) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Plasma kynurenine levels in major depressive disorder ( 29317604) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Psoriatic arthritis ( 26626624)
Interacting Genes		14 interacting genes: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A RELA SERPINA4 SNRNP35 TRAF2 XRCC6	6 interacting genes: ASPH CCR6 HAP1 MAP4K2 RIF1 VIM
Entrez ID		5871	1672
HPRD ID		04408	03634
Ensembl ID		ENSG00000168067	ENSG00000164825
Uniprot IDs		A0A024R567 Q12851	P60022
PDB IDs			1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
Enriched GO Terms of Interacting Partners?
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