MAP4K2 and SNRNP35

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		MAP4K2	SNRNP35
Description		mitogen-activated protein kinase kinase kinase kinase 2	small nuclear ribonucleoprotein U11/U12 subunit 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Basolateral Plasma Membrane	Nucleus Nucleoplasm U12-type Spliceosomal Complex Nucleolus
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity	MRNA Binding SnRNA Binding
	Biological Process	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade	MRNA Splicing, Via Spliceosome RNA Splicing
Pathways			mRNA Splicing - Minor Pathway
Drugs		Fostamatinib
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)	Educational attainment ( 25201988) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A RELA SERPINA4 SNRNP35 TRAF2 XRCC6	17 interacting genes: - ANKRD11 APP CCDC57 CKS1B CLK3 ILK MAP4K2 MPHOSPH9 PLEKHF2 SBK3 SNAPC3 SRPK2 SYT17 TAB1 TNFSF11 U2AF1
Entrez ID		5871	11066
HPRD ID		04408	15595
Ensembl ID		ENSG00000168067	ENSG00000184209
Uniprot IDs		A0A024R567 Q12851	A0A024RBU2 Q16560
PDB IDs
Enriched GO Terms of Interacting Partners?
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