ATP1A3 and ABCA4

		ATP1A3	ABCA4
Description		ATPase Na+/K+ transporting subunit alpha 3	ATP binding cassette subfamily A member 4
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Integral Component Of Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle	Photoreceptor Outer Segment Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane Rod Photoreceptor Disc Membrane
	Molecular Function	Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding Chaperone Binding Ion Antiporter Activity Involved In Regulation Of Presynaptic Membrane Potential Steroid Hormone Binding	GTPase Activity Transporter Activity Lipid Transporter Activity Retinoid Binding 11-cis Retinal Binding All-trans Retinal Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity Retinol Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity ABC-type Transporter Activity
	Biological Process	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Retinol Transport Retinal Metabolic Process Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport
Drugs		Ouabain
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)	D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ABCA4 ASH2L ATRX ATXN1 CASP8 DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229	2 interacting genes: ATP1A3 CNGB1
Entrez ID		478	24
HPRD ID		01666	03408
Ensembl ID		ENSG00000105409	ENSG00000198691
Uniprot IDs		P13637 Q53ES0	P78363 Q6AI28
PDB IDs			7LKP 7LKZ
Enriched GO Terms of Interacting Partners?
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