ABCA4 and CNGB1

Number of citations of the paper that reports this interaction (PubMedID 10466724)
44

Data Source:
HPRD (in vivo)

		ABCA4	CNGB1
Description		ATP binding cassette subfamily A member 4	cyclic nucleotide gated channel subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane Rod Photoreceptor Disc Membrane	Photoreceptor Outer Segment Plasma Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Terminal Bouton Ciliary Membrane Transmembrane Transporter Complex
	Molecular Function	GTPase Activity Transporter Activity Lipid Transporter Activity Retinoid Binding 11-cis Retinal Binding All-trans Retinal Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity Retinol Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity ABC-type Transporter Activity	Intracellular CAMP-activated Cation Channel Activity Intracellular CGMP-activated Cation Channel Activity Protein Binding Ligand-gated Ion Channel Activity CAMP Binding CGMP Binding Protein-containing Complex Binding
	Biological Process	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Retinol Transport Retinal Metabolic Process Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport	Retina Homeostasis Cation Transport Visual Perception Phototransduction Positive Regulation Of Gene Expression Olfactory Nerve Maturation Protein Localization To Organelle Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Cation Transmembrane Transport Ion Channel Modulating, G Protein-coupled Receptor Signaling Pathway Response To Odorant
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)	Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)
Interacting Genes		2 interacting genes: ATP1A3 CNGB1	3 interacting genes: ABCA4 PNN PRPH2
Entrez ID		24	1258
HPRD ID		03408	07204
Ensembl ID		ENSG00000198691	ENSG00000070729
Uniprot IDs		P78363 Q6AI28	Q14028
PDB IDs		7LKP 7LKZ
Enriched GO Terms of Interacting Partners?
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