ATP1A3 and DUSP4

		ATP1A3	DUSP4
Description		ATPase Na+/K+ transporting subunit alpha 3	dual specificity phosphatase 4
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Integral Component Of Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Amyloid-beta Binding P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding Chaperone Binding Ion Antiporter Activity Involved In Regulation Of Presynaptic Membrane Potential Steroid Hormone Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity
	Biological Process	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane	Endoderm Formation Dephosphorylation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway
Drugs		Ouabain
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)	Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Prostate cancer ( 33293427) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)
Interacting Genes		11 interacting genes: ABCA4 ASH2L ATRX ATXN1 CASP8 DUSP4 LYPD3 PPFIA3 PRKD2 TRIM29 ZNF229	21 interacting genes: APP ATP1A3 CRMP1 GORASP2 GRIN1 GRIN2D IDO1 LYSMD1 LYSMD2 LZTS2 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NOXA1 PLEKHF2 TEPSIN TRAF1 ZNF426 ZNF655
Entrez ID		478	1846
HPRD ID		01666	04123
Ensembl ID		ENSG00000105409	ENSG00000120875
Uniprot IDs		P13637 Q53ES0	Q13115
PDB IDs			3EZZ
Enriched GO Terms of Interacting Partners?
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