MPZ and HSPA6

		MPZ	HSPA6
Description		myelin protein zero	heat shock protein family A (Hsp70) member 6
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GO Annotations	Cellular Component	Lysosome Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Myelin Sheath Synapse	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Structural Molecule Activity	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Chemical Synaptic Transmission Myelination Negative Regulation Of Apoptotic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Aggregation	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Visceral adipose tissue adjusted for BMI ( 22589738)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		6 interacting genes: DEDD HSPA6 PINX1 PMP22 PSMB3 RGS4	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 TERF1
Entrez ID		4359	3310
HPRD ID		01159	00775
Ensembl ID		ENSG00000158887	ENSG00000173110
Uniprot IDs		A0A5F9ZI26 P25189	A0A384NKX5 B3KSM6 P17066
PDB IDs		1N2P 3OAI	3FE1
Enriched GO Terms of Interacting Partners?
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