HSPA6 and PRAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSPA6	PRAP1
Description		heat shock protein family A (Hsp70) member 6	proline rich acidic protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Extracellular Region Endoplasmic Reticulum
	Molecular Function	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Protein Binding Triglyceride Binding
	Biological Process	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation	Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Apoptotic Process Cellular Response To X-ray Deactivation Of Mitotic Spindle Assembly Checkpoint Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Triglyceride Transport Positive Regulation Of Phospholipid Transport
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)	Nonunion in individuals with fractures ( 30680360)
Interacting Genes		18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 TERF1	11 interacting genes: AHNAK2 ASPH CEP19 GRB2 HSPA6 MEOX2 MRFAP1 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		3310	118471
HPRD ID		00775	17898
Ensembl ID		ENSG00000173110	ENSG00000165828
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	A6XND8 Q96NZ9
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?
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