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MDM2 and ZNF420
Number of citations of the paper that reports this interaction (PubMedID
25691462
)
0
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
MDM2
ZNF420
Description
MDM2 proto-oncogene
zinc finger protein 420
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Endocytic Vesicle Membrane
Protein-containing Complex
Synapse
Nucleus
Nucleoplasm
Molecular Function
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
5S RRNA Binding
Zinc Ion Binding
Ligase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Receptor Serine/threonine Kinase Binding
Identical Protein Binding
Peroxisome Proliferator Activated Receptor Binding
Ribonucleoprotein Complex Binding
Ubiquitin Binding
Protein N-terminus Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Disordered Domain Specific Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Blood Vessel Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Atrioventricular Valve Morphogenesis
Endocardial Cushion Morphogenesis
Ventricular Septum Development
Atrial Septum Development
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Traversing Start Control Point Of Mitotic Cell Cycle
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Iron Ion
Positive Regulation Of Gene Expression
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Protein Ubiquitination
Protein Sumoylation
Protein Destabilization
Response To Magnesium Ion
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Transcription Factor Catabolic Process
Regulation Of Protein Catabolic Process
Response To Cocaine
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Morphine
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Establishment Of Protein Localization
Response To Ether
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Response To Antibiotic
Positive Regulation Of Protein Export From Nucleus
Response To Steroid Hormone
Positive Regulation Of Muscle Cell Differentiation
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Cell Cycle
Protein Autoubiquitination
Cardiac Septum Morphogenesis
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
Cellular Response To Vitamin B1
Cellular Response To Alkaloid
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Hypoxia
Cellular Response To Gamma Radiation
Cellular Response To UV-C
Cellular Response To Actinomycin D
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Response To Formaldehyde
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Amyloid Fibril Formation
Response To Water-immersion Restraint Stress
Regulation Of Transcription By RNA Polymerase II
Pathways
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Constitutive Signaling by AKT1 E17K in Cancer
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity
Generic Transcription Pathway
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Zinc
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Pneumoconiosis in silica exposure (
24986923
)
Red blood cell count (
32888494
)
Body shape index (
34021172
)
Eosinophil percentage of white cells (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
Plateletcrit (
32888494
)
Prudent dietary pattern (
28644415
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
261 interacting genes:
ABL1
ABL2
ADRB2
AKAP5
AKT1
ANKRD17
APEX1
APP
AR
ARRB1
ARRB2
ATF4
ATM
ATP2A2
ATRX
AURKA
BAIAP2L1
BRINP1
BTK
BTRC
CANX
CASP2
CASP3
CCAR1
CCNG1
CDC34
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CSNK2A1
CSNK2A2
CSNK2B
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DDX24
DDX42
DHFR
DLG4
DNAJB4
DYRK2
EGLN3
EID1
EP300
ESR1
EZR
F3
FBXO31
FGFR2
FHL2
FKBP1A
FOS
FOXO1
FOXO3
FOXP3
G3BP2
GADD45A
GCAT
GLIS2
GNL3
GORAB
GRK2
GSK3B
GTF2E2
GYS2
H2BC21
H3-4
HCK
HDAC1
HEY1
HIF1A
HIPK2
HLA-DMB
HMGA2
HMGN1
HNRNPK
HSP90B1
IER3
IGF1R
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
KPNA1
LMO7
MAGEA2
MAP1LC3A
MAP2
MAPKAPK2
MDM4
MED1
MKRN3
MS4A1
MTBP
MYC
MYD88
MYDGF
NACA
NAT10
NCL
NDUFS1
NGFR
NOLC1
NOP53
NOTCH1
NPIPB3
NPM1
NR3C1
NUCKS1
NUMB
PAK6
PBX1
PBXIP1
PDE4D
PDIA3
PDLIM7
PDS5A
PER2
PGAM2
PHF7
PHLDB3
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PPP1R10
PRDM2
PRKN
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RAD23A
RANBP1
RANBP2
RARA
RASSF1
RB1
RBBP6
RBM10
RBM38
RCHY1
RESF1
RIDA
RLIM
RNF10
RNF126
RNF8
RPL11
RPL22
RPL26
RPL36A
RPL4
RPL5
RPS23
RPS27A
RPS3
RPS5
RRM2B
RRP1
RSL1D1
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SENP3
SESN2
SET
SETD7
SETDB1
SHPK
SIRT2
SIRT3
SMARCA2
SMARCA4
SMARCE1
SMG7
SORBS2
SRC
SREK1
SRSF11
STK11
SUMO1
TAF1
TBP
TCAP
TERT
TFIP11
TOP1
TP53
TP53I3
TP53RK
TP73
TPR
TPT1
TRAF5
TRIM13
TRIM23
TRIM27
TRIM4
TRIM9
TSG101
UBB
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2J2
UBE2K
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP15
USP2
USP7
VEGFA
WRN
WT1
XBP1
XIAP
XPC
YY1AP1
ZNF133
ZNF420
15 interacting genes:
C1orf109
CDC42
CDK2AP1
CDKN2A
CEP19
CYP4V2
CYP51A1
EXOSC5
HAX1
KRTAP10-7
MDM2
SLC1A7
TNFRSF1B
TRIM28
ZNF76
Entrez ID
4193
147923
HPRD ID
01272
08122
Ensembl ID
ENSG00000135679
ENSG00000197050
Uniprot IDs
A0A0A8KB75
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
Q8TAQ5
PDB IDs
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2MPS
2RUH
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3MQS
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4HG7
4JV7
4JV9
4JVE
4JVR
4JWR
4MDN
4MDQ
4OAS
4OBA
4OCC
4ODE
4ODF
4OGN
4OGT
4OGV
4OQ3
4QO4
4QOC
4UD7
4UE1
4UMN
4WT2
4XXB
4ZFI
4ZGK
4ZYC
4ZYF
4ZYI
5AFG
5C5A
5HMH
5HMI
5HMK
5J7F
5J7G
5LAV
5LAW
5LAY
5LAZ
5LN2
5MNJ
5OAI
5OC8
5SWK
5TRF
5UMM
5VK0
5WTS
5XXK
5Z02
5ZXF
6AAW
6GGN
6H22
6HFA
6I29
6I3S
6IM9
6KZU
6Q96
6Q9H
6Q9L
6Q9O
6SQO
6T2D
6T2E
6T2F
6Y4Q
7AD0
7AI0
7AI1
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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