MDM2 and RPL5

Number of citations of the paper that reports this interaction (PubMedID 14612427)
247

Data Source:
HPRD (in vivo)

		MDM2	RPL5
Description		MDM2 proto-oncogene	ribosomal protein L5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Body Endocytic Vesicle Membrane Protein-containing Complex Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Disordered Domain Specific Binding	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Traversing Start Control Point Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Iron Ion Positive Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Protein Ubiquitination Protein Sumoylation Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Transcription Factor Catabolic Process Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Morphine Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Establishment Of Protein Localization Response To Ether Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Cellular Response To Actinomycin D Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways		AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Pneumoconiosis in silica exposure ( 24986923) Red blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 19525955 17660530)
Interacting Genes		261 interacting genes: ABL1 ABL2 ADRB2 AKAP5 AKT1 ANKRD17 APEX1 APP AR ARRB1 ARRB2 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDC34 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 EGLN3 EID1 EP300 ESR1 EZR F3 FBXO31 FGFR2 FHL2 FKBP1A FOS FOXO1 FOXO3 FOXP3 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KPNA1 LMO7 MAGEA2 MAP1LC3A MAP2 MAPKAPK2 MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NDUFS1 NGFR NOLC1 NOP53 NOTCH1 NPIPB3 NPM1 NR3C1 NUCKS1 NUMB PAK6 PBX1 PBXIP1 PDE4D PDIA3 PDLIM7 PDS5A PER2 PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PRKN PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM10 RBM38 RCHY1 RESF1 RIDA RLIM RNF10 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS27A RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SORBS2 SRC SREK1 SRSF11 STK11 SUMO1 TAF1 TBP TCAP TERT TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420	26 interacting genes: CLK1 CSNK2A1 CSNK2B DCC EIF5A ERCC6 HARS1 IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL OGT PDCD4 PPM1D RNA5S7 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL
Entrez ID		4193	6125
HPRD ID		01272	04699
Ensembl ID		ENSG00000135679	ENSG00000122406
Uniprot IDs		A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0	A2RUM7 P46777
PDB IDs		1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6HFA 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 6SQO 6T2D 6T2E 6T2F 6Y4Q 7AD0 7AI0 7AI1	4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP
Enriched GO Terms of Interacting Partners?
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