MDM2 and BTRC

Number of citations of the paper that reports this interaction (PubMedID 20708156)
111

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		MDM2	BTRC
Description		MDM2 proto-oncogene	beta-transducin repeat containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Body Endocytic Vesicle Membrane Protein-containing Complex Synapse	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Disordered Domain Specific Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Traversing Start Control Point Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Iron Ion Positive Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Protein Ubiquitination Protein Sumoylation Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Transcription Factor Catabolic Process Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Morphine Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Establishment Of Protein Localization Response To Ether Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Cellular Response To Actinomycin D Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress	Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Pneumoconiosis in silica exposure ( 24986923) Red blood cell count ( 32888494)	Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)
Interacting Genes		261 interacting genes: ABL1 ABL2 ADRB2 AKAP5 AKT1 ANKRD17 APEX1 APP AR ARRB1 ARRB2 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDC34 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 EGLN3 EID1 EP300 ESR1 EZR F3 FBXO31 FGFR2 FHL2 FKBP1A FOS FOXO1 FOXO3 FOXP3 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KPNA1 LMO7 MAGEA2 MAP1LC3A MAP2 MAPKAPK2 MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NDUFS1 NGFR NOLC1 NOP53 NOTCH1 NPIPB3 NPM1 NR3C1 NUCKS1 NUMB PAK6 PBX1 PBXIP1 PDE4D PDIA3 PDLIM7 PDS5A PER2 PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PRKN PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM10 RBM38 RCHY1 RESF1 RIDA RLIM RNF10 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS27A RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SORBS2 SRC SREK1 SRSF11 STK11 SUMO1 TAF1 TBP TCAP TERT TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420	86 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 DPCD E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LINC00511 LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A
Entrez ID		4193	8945
HPRD ID		01272	04596
Ensembl ID		ENSG00000135679	ENSG00000166167
Uniprot IDs		A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0	A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297
PDB IDs		1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6HFA 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 6SQO 6T2D 6T2E 6T2F 6Y4Q 7AD0 7AI0 7AI1	1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?
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