LRPAP1 and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 10783161)
54

Data Source:
BioGRID (two hybrid)

		LRPAP1	RALGDS
Description		LDL receptor related protein associated protein 1	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Rough Endoplasmic Reticulum Lumen	Nucleus Cytosol Brush Border
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Protein Binding Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cell Death Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Signaling Receptor Activity	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity
Pathways			p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		18 interacting genes: ASPH ETV7 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SORL1 SORT1 VLDLR	27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10
Entrez ID		4043	5900
HPRD ID		00082	03371
Ensembl ID		ENSG00000163956	ENSG00000160271
Uniprot IDs		P30533	Q12967 Q8N4Y1
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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