RALGDS and MRAS

Number of citations of the paper that reports this interaction (PubMedID 9400994)
20

Data Source:
HPRD (two hybrid, in vitro)

		RALGDS	MRAS
Description		ral guanine nucleotide dissociation stimulator	muscle RAS oncogene homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 24262325 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10	11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU
Entrez ID		5900	22808
HPRD ID		03371	06662
Ensembl ID		ENSG00000160271	ENSG00000158186
Uniprot IDs		Q12967 Q8N4Y1	O14807 Q6FGP0 Q8WVM9
PDB IDs		1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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