RALGDS and AFDN

Number of citations of the paper that reports this interaction (PubMedID 10545207)
27

Data Source:
HPRD (two hybrid)

		RALGDS	AFDN
Description		ral guanine nucleotide dissociation stimulator	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10	39 interacting genes: BCR CCR6 CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		5900	4301
HPRD ID		03371	01164
Ensembl ID		ENSG00000160271	ENSG00000130396
Uniprot IDs		Q12967 Q8N4Y1	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		1RAX 2B3A 2RGF 3KH0	1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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