RALGDS and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		RALGDS	RRAS2
Description		ral guanine nucleotide dissociation stimulator	RAS related 2
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GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	RND1 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10	32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		5900	22800
HPRD ID		03371	02518
Ensembl ID		ENSG00000160271	ENSG00000133818
Uniprot IDs		Q12967 Q8N4Y1	P62070
PDB IDs		1RAX 2B3A 2RGF 3KH0	2ERY
Enriched GO Terms of Interacting Partners?
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