LRPAP1 and SORL1

Number of citations of the paper that reports this interaction (PubMedID 8940146)
73

Data Source:
HPRD (in vivo, in vitro)

		LRPAP1	SORL1
Description		LDL receptor related protein associated protein 1	sortilin related receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Rough Endoplasmic Reticulum Lumen	Golgi Membrane Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Early Endosome Membrane Golgi Cisterna Multivesicular Body Membrane Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Perinucleolar Compartment
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding Small GTPase Binding Neuropeptide Binding
	Biological Process	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Protein Binding Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cell Death Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Signaling Receptor Activity	Diet Induced Thermogenesis Protein Targeting Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Neuropeptide Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Protein Localization To Golgi Apparatus Insulin Receptor Recycling Negative Regulation Of MAP Kinase Activity Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Neurogenesis Protein Maturation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Death Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Choline O-acetyltransferase Activity Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Adipose Tissue Development Adaptive Thermogenesis Positive Regulation Of Endocytic Recycling
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 23565137 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Atrial fibrillation ( 30061737 29892015) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Cadmium levels ( 26025379) Cardiovascular risk factors (age interaction) ( 20838585) Estimated glomerular filtration rate ( 31152163 31451708) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Mood disorder in prion disease ( 25897833) Non-word reading ( 30741946) Problematic alcohol use ( 32451486) Rheumatic heart disease ( 34106200) Smoking status (ever vs never smokers) ( 30643258) Spontaneous preterm birth (preterm birth) ( 25599974) Word reading ( 30741946)
Interacting Genes		18 interacting genes: ASPH ETV7 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SORL1 SORT1 VLDLR	10 interacting genes: APOE FURIN GGA1 GGA2 HSPA12A LRPAP1 POU6F2 PPP1CA RHOH SORT1
Entrez ID		4043	6653
HPRD ID		00082	03595
Ensembl ID		ENSG00000163956	ENSG00000137642
Uniprot IDs		P30533	A0A024R3H2 Q92673
PDB IDs		1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03	2DM4 3G2S 3G2T 3WSX 3WSY 3WSZ
Enriched GO Terms of Interacting Partners?
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