ARAF and PKM

Number of citations of the paper that reports this interaction (PubMedID 12620389)
13

Data Source:
BioGRID (imaging technique)
HPRD (two hybrid)

		ARAF	PKM
Description		A-Raf proto-oncogene, serine/threonine kinase	pyruvate kinase M1/2
Image
GO Annotations	Cellular Component	Cellular_component Mitochondrion Cytosol	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Magnesium Ion Binding RNA Binding MRNA Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Cadherin Binding
	Biological Process	MAPK Cascade Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process	Glycolytic Process Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Neutrophil degranulation
Drugs		ATP	Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Copper Artenimol
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301)
Interacting Genes		58 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG	63 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CDKN1A CTNNB1 DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MDM2 MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 PAX8 PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 SUMO1 SUMO2 TERF1 TINF2 TK1 TRIM35 TRIM55 TRIM63 UBE3A UCHL5 USP7 YWHAQ
Entrez ID		369	5315
HPRD ID		02405	01529
Ensembl ID		ENSG00000078061	ENSG00000067225
Uniprot IDs		A0A024R178 P10398 Q96II5	A0A024R5Z9 B4DNK4 P14618 V9HWB8
PDB IDs		1WXM 2MSE	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?