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ARAF and PDGFRB
Number of citations of the paper that reports this interaction (PubMedID
15763428
)
7
Data Source:
HPRD
(in vivo, in vitro)
ARAF
PDGFRB
Description
A-Raf proto-oncogene, serine/threonine kinase
platelet derived growth factor receptor beta
Image
GO Annotations
Cellular Component
Cellular_component
Mitochondrion
Cytosol
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Receptor Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Biological Process
MAPK Cascade
Cellular Protein Modification Process
Protein Phosphorylation
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Angiogenesis
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Multicellular Organism Development
Aging
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Kinase Activity
Response To Fluid Shear Stress
Positive Regulation Of Rho Protein Signal Transduction
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Positive Regulation Of Chemotaxis
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Lung Growth
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of DNA Biosynthetic Process
Pathways
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
ATP
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Interacting Genes
58 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
BRAF
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
84 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CDK14
CDX1
CEP76
CHRM3
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FAXDC2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
ITK
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
MITF
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SLC9A3R1
SLC9A3R2
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TUFM
TYK2
VAV1
YES1
Entrez ID
369
5159
HPRD ID
02405
01423
Ensembl ID
ENSG00000078061
ENSG00000113721
Uniprot IDs
A0A024R178
P10398
Q96II5
P09619
Q59F04
PDB IDs
1WXM
2MSE
1GQ5
1H9O
1LWP
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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