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ARAF and KLHL12
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
1103
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ARAF
KLHL12
Description
A-Raf proto-oncogene, serine/threonine kinase
kelch like family member 12
Image
GO Annotations
Cellular Component
Cellular_component
Mitochondrion
Cytosol
Cytosol
COPII Vesicle Coat
COPII-coated ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Centriolar Satellite
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Cellular Protein Modification Process
Protein Phosphorylation
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Neural Crest Formation
Neural Crest Cell Development
Wnt Signaling Pathway
COPII Vesicle Coating
Pathways
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
Degradation of DVL
Drugs
ATP
Diseases
GWAS
Interacting Genes
58 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
BRAF
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
62 interacting genes:
ARAF
ARRDC1
ATXN1
BAG6
BCL6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CRTC3
CUL3
DGCR6
DRD4
DVL2
DVL3
FAM90A1
FBXL17
FGD2
FLNA
GLYCTK
INMT
KEAP1
KHSRP
KLHL2
KLHL24
KLHL3
LNPK
LNX1
MAPRE1
MED25
MED28
MPP1
MRPL10
MTNR1A
MYO15B
NDC80
NTAQ1
PDGFRB
PEA15
PEF1
PLEKHA4
PNKP
PRR13
RGL3
RIN1
RIT1
RNF4
RPP25L
SDCBP
SEC31A
SNX20
SYNE4
TAOK2
TBC1D10C
TCEANC
TTBK2
UBE2I
VEGFB
VTA1
ZBP1
ZBTB4
Entrez ID
369
59349
HPRD ID
02405
13925
Ensembl ID
ENSG00000078061
ENSG00000117153
Uniprot IDs
A0A024R178
P10398
Q96II5
Q53G59
Q9H7R2
PDB IDs
1WXM
2MSE
2VPJ
6TTK
6V7O
Enriched GO Terms of Interacting Partners
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