TNC and POLE3

		TNC	POLE3
Description		tenascin C	DNA polymerase epsilon 3, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Wound Healing Odontogenesis Of Dentin-containing Tooth Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	DNA Replication Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process
Pathways		Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 29875488 28240269) Developmental language disorder (syntactic complexity) ( 27016271) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Response to bupropion and depression ( 27622933)
Interacting Genes		16 interacting genes: ANXA2 ASTN2 CNTN1 EGFR FN1 ITGA5 ITGB1 MBD1 NCAN POLE3 PTPRB RAB14 SMOC1 SMOC2 SPARC TRIM32	14 interacting genes: ALAD APP ASTN2 BAZ1A CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32
Entrez ID		3371	54107
HPRD ID		01756	06274
Ensembl ID		ENSG00000041982	ENSG00000148229
Uniprot IDs		B4E1W8 J3QSU6 P24821 Q4LE33	A0A024R829 Q9NRF9
PDB IDs		1TEN 2RB8 2RBL 5R5T 5R5U 5R5V 5R5W 5R5X 5R5Y 5R5Z 5R60 5R61 5R62 5R63 6BRB 6QNV
Enriched GO Terms of Interacting Partners?
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