PCLO and GIT2

Number of citations of the paper that reports this interaction (PubMedID 12473661)
56

Data Source:
BioGRID (two hybrid)

		PCLO	GIT2
Description		piccolo presynaptic cytomatrix protein	GIT ArfGAP 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Postsynaptic Density Axon Synapse Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse	Nucleoplasm Focal Adhesion
	Molecular Function	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Structural Constituent Of Presynaptic Active Zone	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Synaptic Vesicle Clustering Presynapse To Nucleus Signaling Pathway Presynaptic Active Zone Assembly	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity
Pathways		Sensory processing of sound by inner hair cells of the cochlea	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 21621269 28540843 20351715) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 33169155)	Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		4 interacting genes: ERC2 GIT1 GIT2 PCAT1	48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		27445	9815
HPRD ID		16078	09779
Ensembl ID		ENSG00000186472	ENSG00000139436
Uniprot IDs		Q9Y6V0	F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58
PDB IDs		1UJD
Enriched GO Terms of Interacting Partners?
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