GDF9 and FXYD6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GDF9	FXYD6
Description		growth differentiation factor 9	FXYD domain containing ion transport regulator 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding	Molecular_function Protein Binding Sodium Channel Regulator Activity
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway SMAD Protein Signal Transduction Regulation Of Progesterone Secretion	Ion Transport Biological_process Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Asthma ( 31619474)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		46 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G HSPA9 ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3 WASHC3	65 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35C2 SLC35E1 SLC35E3 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119
Entrez ID		2661	53826
HPRD ID		03560	09456
Ensembl ID		ENSG00000164404	ENSG00000137726
Uniprot IDs		B4DXG3 O60383	A0A024R3J8 Q9H0Q3
PDB IDs
Enriched GO Terms of Interacting Partners?
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