FXYD6 and ELOVL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FXYD6	ELOVL2
Description		FXYD domain containing ion transport regulator 6	ELOVL fatty acid elongase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Molecular_function Protein Binding Sodium Channel Regulator Activity	Protein Binding Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity
	Biological Process	Ion Transport Biological_process Regulation Of Sodium Ion Transmembrane Transporter Activity	Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs
Drugs			alpha-Linolenic acid
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)	Adverse response to drug ( 30420678) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Glycerophospholipid levels ( 26068415) Metabolic traits ( 21886157) Metabolite levels ( 22916037) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		65 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35C2 SLC35E1 SLC35E3 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119	4 interacting genes: FXYD6 IFITM3 MALL TMEM218
Entrez ID		53826	54898
HPRD ID		09456	16857
Ensembl ID		ENSG00000137726	ENSG00000197977
Uniprot IDs		A0A024R3J8 Q9H0Q3	A0A024QZV3 Q9NXB9
PDB IDs
Enriched GO Terms of Interacting Partners?
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