GDF9 and ORAI2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GDF9	ORAI2
Description		growth differentiation factor 9	ORAI calcium release-activated calcium modulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding	Protein Binding Store-operated Calcium Channel Activity
	Biological Process	Oocyte Growth Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth BMP Signaling Pathway SMAD Protein Signal Transduction Regulation Of Progesterone Secretion	Store-operated Calcium Entry Calcium Ion Transmembrane Transport
Pathways			Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Asthma ( 31619474)	Chronotype ( 30696823 27494321) Morning vs. evening chronotype ( 27494321)
Interacting Genes		46 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 DLEU1 DNM2 FOXG1 FXYD6 GADD45G HSPA9 ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TDGF1 TK1 TRIB3 WASHC3	5 interacting genes: COPS6 GDF9 MED31 SETDB1 UNC119
Entrez ID		2661	80228
HPRD ID		03560	09860
Ensembl ID		ENSG00000164404	ENSG00000160991
Uniprot IDs		B4DXG3 O60383	B4DUB4 Q96SN7
PDB IDs
Enriched GO Terms of Interacting Partners?
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