DEFB121 and IL27RA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DEFB121	IL27RA
Description		defensin beta 121	interleukin 27 receptor subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Molecular_function Protein Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity
	Biological Process	Defense Response To Bacterium Innate Immune Response	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		Beta defensins Defensins	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Prudent dietary pattern ( 28644415)	Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		10 interacting genes: CD40 CLEC2D FAM209A GJA8 IL27RA LAYN LRRC25 NECTIN4 SSMEM1 SYNE4	13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6
Entrez ID		245934	9466
HPRD ID		16791	09247
Ensembl ID		ENSG00000204548	ENSG00000104998
Uniprot IDs		A0A384MDM0 Q5GRF9 Q5J5C9	Q6UWB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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