IL27RA and EBI3

Number of citations of the paper that reports this interaction (PubMedID 12121660)
437

Data Source:
HPRD (in vivo, in vitro)

		IL27RA	EBI3
Description		interleukin 27 receptor subunit alpha	Epstein-Barr virus induced 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity	Cytokine Receptor Activity Cytokine Activity Protein Binding Peptide Hormone Binding Cytokine Binding
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Humoral Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Leptin-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of Alpha-beta T Cell Proliferation
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Interleukin-35 Signalling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Triglyceride levels ( 32154731)
Interacting Genes		13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6	6 interacting genes: CANX GOSR1 IL12A IL27RA MDFI SMAD3
Entrez ID		9466	10148
HPRD ID		09247	12051
Ensembl ID		ENSG00000104998	ENSG00000105246
Uniprot IDs		Q6UWB1	Q14213
PDB IDs
Enriched GO Terms of Interacting Partners?
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