IL27RA and MFSD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL27RA	MFSD5
Description		interleukin 27 receptor subunit alpha	major facilitator superfamily domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity	Protein Binding Molybdate Ion Transmembrane Transporter Activity
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Molybdate Ion Transport
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6	61 interacting genes: ADGRE2 AQP6 ARL6IP1 BEST2 BLCAP BTNL9 C2CD2L CBARP CCL4L2 CD40 CD79A CLDN7 CLRN1 CREB3 CREB3L1 CYB5B ERRFI1 FFAR2 FXYD3 GJA5 GLP1R GOSR2 GPR101 GPR152 GPR25 GPR42 GPX8 HSD17B13 IGFBP5 IL27RA KASH5 LAT LHFPL5 LMNA MMGT1 MUC1 PEX19 PGRMC2 PKMYT1 PLN RNF144A RNF19B RTP2 SCN3B SEC22B SHISAL1 SLC10A6 SLC18A2 SLC39A9 SSMEM1 STATH TBXA2R TIMMDC1 TMEM128 TMEM130 TMEM14B TMEM179B TMEM203 TMEM237 XRN1 YIPF6
Entrez ID		9466	84975
HPRD ID		09247	14416
Ensembl ID		ENSG00000104998	ENSG00000182544
Uniprot IDs		Q6UWB1	Q6N075
PDB IDs
Enriched GO Terms of Interacting Partners?
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