RRAS2 and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RRAS2	RAP1GDS1
Description		RAS related 2	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	GTPase Activator Activity Protein Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		RND1 GTPase cycle	RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		22800	5910
HPRD ID		02518	11763
Ensembl ID		ENSG00000133818	ENSG00000138698
Uniprot IDs		P62070	B3KNU0 P52306 Q6U7G8
PDB IDs		2ERY	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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