AFP and EHD4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		AFP	EHD4
Description		alpha fetoprotein	EH domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen	Nucleus Cytoplasm Early Endosome Endoplasmic Reticulum Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Fatty Acid Binding Protein Binding Zinc Ion Binding	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Cadherin Binding
	Biological Process	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction	Endocytosis Pinocytosis Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Homooligomerization Cilium Assembly Cellular Response To Growth Factor Stimulus Protein Localization To Plasma Membrane
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)	Adverse response to drug ( 30420678) Granulocyte count ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP	4 interacting genes: AFP CDC42 RASGRF1 SUMO2
Entrez ID		174	30844
HPRD ID		00074	10435
Ensembl ID		ENSG00000081051	ENSG00000103966
Uniprot IDs		P02771	A0A024R9N6 A8K9B9 Q9H223
PDB IDs		3MRK
Enriched GO Terms of Interacting Partners?
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