EHD4 and RASGRF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		EHD4	RASGRF1
Description		EH domain containing 4	Ras protein specific guanine nucleotide releasing factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Endoplasmic Reticulum Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Cytosol Plasma Membrane Growth Cone Neuron Projection
	Molecular Function	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding
	Biological Process	Endocytosis Pinocytosis Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Homooligomerization Cilium Assembly Cellular Response To Growth Factor Stimulus Protein Localization To Plasma Membrane	Signal Transduction Small GTPase Mediated Signal Transduction Long-term Memory Cell Population Proliferation Neuron Projection Development Response To Endoplasmic Reticulum Stress Regulation Of Rac Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Activation Of GTPase Activity Regulation Of NMDA Receptor Activity
Pathways			Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Granulocyte count ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 23396134 32231278 20835236) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: AFP CDC42 RASGRF1 SUMO2	19 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 TNK2 USP8 YWHAB YWHAE
Entrez ID		30844	5923
HPRD ID		10435	07362
Ensembl ID		ENSG00000103966	ENSG00000058335
Uniprot IDs		A0A024R9N6 A8K9B9 Q9H223	A8K270 Q13972 Q8IUU5
PDB IDs
Enriched GO Terms of Interacting Partners?
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