AFP and SGSM2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AFP	SGSM2
Description		alpha fetoprotein	small G protein signaling modulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen	Cytoplasm Melanosome
	Molecular Function	Fatty Acid Binding Protein Binding Zinc Ion Binding	GTPase Activator Activity Small GTPase Binding
	Biological Process	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction	Intracellular Protein Transport Late Endosome To Golgi Transport Positive Regulation Of GTPase Activity Activation Of GTPase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)	Aortic root size ( 19584346) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fasting blood proinsulin levels ( 23263489) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Proinsulin levels ( 21873549) Schizophrenia ( 25056061)
Interacting Genes		14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP	20 interacting genes: AFP CA12 CELSR3 CHD3 EGFR FNBP1L GDPD2 ILF2 KHDRBS3 MPP1 MTDH PNO1 PTN RAB2A RAB2B RAB3A RAB3B RAB9B RGMA RPS25
Entrez ID		174	9905
HPRD ID		00074	15284
Ensembl ID		ENSG00000081051	ENSG00000141258
Uniprot IDs		P02771	B9A6J3 O43147
PDB IDs		3MRK
Enriched GO Terms of Interacting Partners?
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