COMMD6 and SHMT2

		COMMD6	SHMT2
Description		COMM domain containing 6	serine hydroxymethyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex
	Molecular Function	Protein Binding NF-kappaB Binding	Translation Repressor Activity, MRNA Regulatory Element Binding Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	Negative Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration
Pathways		Neddylation	Metabolism of folate and pterines RHOG GTPase cycle
Drugs			Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)
Interacting Genes		5 interacting genes: COMMD1 COMMD9 HSPA6 MYCBP2 SHMT2	28 interacting genes: ABRAXAS2 ACVR1B APP ARL6IP1 BABAM1 BABAM2 BRCC3 CAB39 CFTR CLEC2D CMTM5 COMMD6 CREB3 CSNK2B DUX4 ESR1 FBXO7 KASH5 KMT2D MAL2 NDRG1 NKD2 OGT PPARD PRKAG1 RND1 SCAF11 TUBA1C
Entrez ID		170622	6472
HPRD ID		13084	00717
Ensembl ID		ENSG00000188243	ENSG00000182199
Uniprot IDs		Q7Z4G1	A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06
PDB IDs			4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F
Enriched GO Terms of Interacting Partners?
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