COMMD6 and HSPA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COMMD6	HSPA6
Description		COMM domain containing 6	heat shock protein family A (Hsp70) member 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding NF-kappaB Binding	Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Negative Regulation Of NF-kappaB Transcription Factor Activity	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation
Pathways		Neddylation	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		5 interacting genes: COMMD1 COMMD9 HSPA6 MYCBP2 SHMT2	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FCGR2B FLNA KRT222 LGALS7 LGALS7B MPZ PPIB PRAP1 RPA1 TERF1
Entrez ID		170622	3310
HPRD ID		13084	00775
Ensembl ID		ENSG00000188243	ENSG00000173110
Uniprot IDs		Q7Z4G1	A0A384NKX5 B3KSM6 P17066
PDB IDs			3FE1
Enriched GO Terms of Interacting Partners?
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