SHMT2 and SCAF11

		SHMT2	SCAF11
Description		serine hydroxymethyltransferase 2	SR-related CTD associated factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex	Nucleoplasm Nucleolus Nuclear Body
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding	RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing
Pathways		Metabolism of folate and pterines RHOG GTPase cycle
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)	Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Hemoglobin levels ( 32327693) Morning person ( 30696823) Multiple sclerosis ( 31604244) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: ABRAXAS2 ACVR1B APP ARL6IP1 BABAM1 BABAM2 BRCC3 CAB39 CFTR CLEC2D CMTM5 COMMD6 CREB3 CSNK2B DUX4 ESR1 FBXO7 KASH5 KMT2D MAL2 NDRG1 NKD2 OGT PPARD PRKAG1 RND1 SCAF11 TUBA1C	13 interacting genes: ATXN1L PSEN1 SHMT2 SNRNP70 SRPK1 SRSF1 SRSF2 SRSF3 SRSF4 STAT3 SUMO2 TUBA1C U2AF2
Entrez ID		6472	9169
HPRD ID		00717	04720
Ensembl ID		ENSG00000182199	ENSG00000139218
Uniprot IDs		A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06	Q99590
PDB IDs		4PVF 5V7I 5X3V 6DK3 6H3C 6M5O 6QVG 6QVL 6R8F
Enriched GO Terms of Interacting Partners?
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