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DDIT3 and NFE2L2
Number of citations of the paper that reports this interaction (PubMedID
32911434
)
1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
DDIT3
NFE2L2
Description
DNA damage inducible transcript 3
nuclear factor, erythroid 2 like 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
CAMP Response Element Binding Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
Transcription Regulator Inhibitor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
ER Overload Response
Response To Unfolded Protein
Cell Cycle
Sensory Perception Of Sound
Anterior/posterior Axis Specification
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of CREB Transcription Factor Activity
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Protein Kinase B Signaling
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
ROS sensing by NFE2L2
ROS sensing by NFE2L2
Regulation of HMOX1 expression and activity
Heme signaling
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Body shape index (
34021172
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
69 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CCDC153
CDK6
CEBPA
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFE2L2
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
80 interacting genes:
APEX1
ARFIP2
ARPC2
ATF3
ATF4
ATM
BPTF
BRPF1
BRPF3
BTRC
CASP1
CASP3
CDH1
CEBPG
CERS2
CFAP299
CHD6
COPS7A
CREB3
CREBBP
CREBL2
CREBZF
DDIT3
EIF2AK3
EIF3J
ELF1
ELF3
ELF4
ELF5
ELK1
ETV1
ETV4
ETV6
FBXW11
FOSB
FOSL2
GSK3B
HNRNPR
IRF2
JUN
JUND
KDM1A
KEAP1
KPNA2
KPNA3
KPNA4
LEF1
MAFF
MAFG
MAFK
MAP2K6
MAPK7
MAPK8
NCOR2
NFAT5
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
REL
RELA
SMAD1
SP140
SPIC
STAT3
SUMO1
SUMO2
TADA2A
TBP
TEF
TNNT1
TRIM24
UBE2E2
WAC
ZBTB24
ZNF396
Entrez ID
1649
4780
HPRD ID
00529
02732
Ensembl ID
ENSG00000175197
ENSG00000116044
Uniprot IDs
P35638
Q53YD1
Q16236
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
Enriched GO Terms of Interacting Partners
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