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DDIT3 and POLR1D
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
DDIT3
POLR1D
Description
DNA damage inducible transcript 3
RNA polymerase I and III subunit D
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
RNA Polymerase III Complex
RNA Polymerase I Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
CAMP Response Element Binding Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
Transcription Regulator Inhibitor Activity
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein Dimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
ER Overload Response
Response To Unfolded Protein
Cell Cycle
Sensory Perception Of Sound
Anterior/posterior Axis Specification
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of CREB Transcription Factor Activity
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Protein Kinase B Signaling
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Transcription, DNA-templated
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Cytosolic sensors of pathogen-associated DNA
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Body mass index (
26426971
)
Interacting Genes
69 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CCDC153
CDK6
CEBPA
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFE2L2
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
14 interacting genes:
CDC25A
CRKL
DDIT3
DNAJB4
DNAJB6
E2F4
GRB2
HAX1
MAGEA11
MRPL12
NFKBIB
NR3C1
POLR1C
PXN
Entrez ID
1649
51082
HPRD ID
00529
17877
Ensembl ID
ENSG00000175197
ENSG00000186184
Uniprot IDs
P35638
Q53YD1
A0A087WTY1
P0DPB5
P0DPB6
PDB IDs
7A6H
7AE1
7AE3
7AEA
7AST
7D58
7D59
Enriched GO Terms of Interacting Partners
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