NFE2L2 and CHD6

Number of citations of the paper that reports this interaction (PubMedID 16314513)
98

Data Source:
HPRD (two hybrid, in vivo)

		NFE2L2	CHD6
Description		nuclear factor, erythroid 2 like 2	chromodomain helicase DNA binding protein 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex	Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Coregulator Binding DNA Binding DNA Helicase Activity ATP Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Inflammatory Response Aging Response To Lithium Ion Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Chromatin Organization DNA Duplex Unwinding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Pathways		ROS sensing by NFE2L2 ROS sensing by NFE2L2 Regulation of HMOX1 expression and activity Heme signaling
Drugs
Diseases
GWAS		Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Diastolic blood pressure ( 27841878) Gastric adenocarcinoma (histologically verified) ( 26098866) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hippocampal atrophy ( 22745009) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Refractive astigmatism ( 30306274) Systolic blood pressure ( 27841878) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Verbal declarative memory ( 25648963) Waist circumference ( 31170924)
Interacting Genes		80 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TNNT1 TRIM24 UBE2E2 WAC ZBTB24 ZNF396	6 interacting genes: ARAF ATXN1L H3-4 NFE2L2 TOLLIP ZFYVE9
Entrez ID		4780	84181
HPRD ID		02732	13049
Ensembl ID		ENSG00000116044	ENSG00000124177
Uniprot IDs		Q16236	Q8TD26
PDB IDs		2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V	2EPB
Enriched GO Terms of Interacting Partners?
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