GRK3 and CCR4

Number of citations of the paper that reports this interaction (PubMedID 10754297)
40

Data Source:
HPRD (in vivo)

		GRK3	CCR4
Description		G protein-coupled receptor kinase 3	C-C motif chemokine receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Receptor Internalization	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		ATP	Mogamulizumab FLX475
Diseases
GWAS			Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		11 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CHEK2 CXCR4 GIT1 HSPB1 OPRM1 SMURF1	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		157	1233
HPRD ID		00183	05324
Ensembl ID		ENSG00000100077	ENSG00000183813
Uniprot IDs		A0A024R1D8 P35626 Q8N433	A0N0Q1 P51679
PDB IDs
Enriched GO Terms of Interacting Partners?
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