CCR4 and NDRG2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		CCR4	NDRG2
Description		C-C motif chemokine receptor 4	NDRG family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Nucleus Cytoplasm Golgi Apparatus Cytosol Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Molecular_function Protein Binding
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Wnt Signaling Pathway Substantia Nigra Development Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Platelet-derived Growth Factor Production
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Mogamulizumab FLX475
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Heart rate response to exercise ( 29769521) Hip circumference adjusted for BMI ( 28552196) Metabolite levels (small molecules and protein measures) ( 27005778) Resting heart rate ( 27798624)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	8 interacting genes: AGTR1 ATP1B1 CCR4 CLN8 CTDP1 MOB2 RABAC1 TRIM32
Entrez ID		1233	57447
HPRD ID		05324	17630
Ensembl ID		ENSG00000183813	ENSG00000165795
Uniprot IDs		A0N0Q1 P51679	Q9UN36
PDB IDs			2XMQ 2XMR 2XMS
Enriched GO Terms of Interacting Partners?
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