GRK3 and GIT1

Number of citations of the paper that reports this interaction (PubMedID 9826657)
91

Data Source:
HPRD (in vivo)

		GRK3	GIT1
Description		G protein-coupled receptor kinase 3	GIT ArfGAP 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Mitochondrion Centrosome Cytosol Focal Adhesion Postsynaptic Density Membrane Lamellipodium Calyx Of Held Mitotic Spindle Pole Postsynapse
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	GTPase Activator Activity Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Receptor Internalization	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Catalytic Activity Motor Learning Cellular Response To Lipopolysaccharide Positive Regulation Of Microtubule Nucleation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis
Pathways		G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis	Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs
Drugs		ATP
Diseases
GWAS			Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CHEK2 CXCR4 GIT1 HSPB1 OPRM1 SMURF1	54 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		157	28964
HPRD ID		00183	06577
Ensembl ID		ENSG00000100077	ENSG00000108262
Uniprot IDs		A0A024R1D8 P35626 Q8N433	Q59FC3 Q9Y2X7
PDB IDs
Enriched GO Terms of Interacting Partners?
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