GRK3 and CXCR4

Number of citations of the paper that reports this interaction (PubMedID 11668182)
26

Data Source:
HPRD (in vivo, in vitro)

		GRK3	CXCR4
Description		G protein-coupled receptor kinase 3	C-X-C motif chemokine receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Receptor Internalization	Response To Hypoxia Neuron Migration Epithelial Cell Development Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Neuron Recognition Response To Virus Response To Activity Calcium-mediated Signaling Neurogenesis Telencephalon Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Vascular Wound Healing CXCL12-activated CXCR4 Signaling Pathway Regulation Of Programmed Cell Death Myelin Maintenance Response To Morphine Endothelial Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Viral Process Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cardiac Muscle Contraction Cell Chemotaxis Endothelial Tube Morphogenesis Cellular Response To Cytokine Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Dendrite Extension Positive Regulation Of Mesenchymal Stem Cell Migration Response To Ultrasound Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		ATP	Framycetin AMD-070 Plerixafor Ibalizumab
Diseases
GWAS			Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 19525953) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CHEK2 CXCR4 GIT1 HSPB1 OPRM1 SMURF1	43 interacting genes: ACAT1 AGO3 ARRB2 ATP13A2 B2M CCR5 CD4 CDRT15P3 CLCN5 COL4A1 CTSG CXCL12 DHX57 DPP4 DUXAP9 ELANE FTO GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RALB RNF113A SCAMP2 SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		157	7852
HPRD ID		00183	01217
Ensembl ID		ENSG00000100077	ENSG00000121966
Uniprot IDs		A0A024R1D8 P35626 Q8N433	A0A0U3FJG0 A0A0U3GXA9 P61073
PDB IDs			2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS
Enriched GO Terms of Interacting Partners?
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