CCR4 and GRK3

Number of citations of the paper that reports this interaction (PubMedID 10754297)
40

Data Source:
HPRD (in vivo)

		CCR4	GRK3
Description		C-C motif chemokine receptor 4	G protein-coupled receptor kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Cytosol Plasma Membrane
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Desensitization Of G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Receptor Internalization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis
Drugs		Mogamulizumab FLX475	ATP
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	11 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CHEK2 CXCR4 GIT1 HSPB1 OPRM1 SMURF1
Entrez ID		1233	157
HPRD ID		05324	00183
Ensembl ID		ENSG00000183813	ENSG00000100077
Uniprot IDs		A0N0Q1 P51679	A0A024R1D8 P35626 Q8N433
PDB IDs
Enriched GO Terms of Interacting Partners?
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