ADRB3 and WRN

		ADRB3	WRN
Description		adrenoceptor beta 3	WRN RecQ like helicase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck Neuron Projection
	Molecular Function	G Protein-coupled Receptor Activity Beta-adrenergic Receptor Activity Protein Binding Beta3-adrenergic Receptor Activity Protein Homodimerization Activity Epinephrine Binding Norepinephrine Binding	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity Chromatin Binding Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATP Hydrolysis Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding
	Biological Process	Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Carbohydrate Metabolic Process Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Receptor-mediated Endocytosis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of MAPK Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Brain Development Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organism Aging Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process G-quadruplex DNA Unwinding Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Replicative Senescence T-circle Formation Positive Regulation Of Strand Invasion Protein Localization To Nucleolus
Pathways		Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		Amphetamine Bethanidine Olanzapine Norepinephrine Nortriptyline Propranolol Paroxetine Trimipramine Cryptenamine Alprenolol Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Fenoterol Ephedra sinica root Mephentermine Clenbuterol Oxprenolol Celiprolol Nebivolol Amibegron Solabegron Droxidopa Bufuralol Bopindolol Bupranolol Mirabegron Racepinephrine Dihydroergocornine DL-Methylephedrine Dihydroergocristine Vibegron
Diseases
GWAS			Chronotype ( 30696823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Daytime sleep phenotypes ( 27126917) Exercise treadmill test traits ( 17903301) Fasting glucose change (long-term) ( 31263163) Intelligence (MTAG) ( 29326435) Lifespan ( 25918517) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Metabolite levels ( 23823483) Morning person ( 30696823)
Interacting Genes		6 interacting genes: ADRB2 GNAS IDO1 SRC UBXN8 WRN	37 interacting genes: ADRB3 ATM ATRX BARD1 BLM BRCA1 C8orf86 CDKN2A FEN1 H2AX HTR5A MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 SUMO1 SUMO2 TERF2 TP53 UBXN8 VCP WRNIP1 XRCC5 XRCC6
Entrez ID		155	7486
HPRD ID		00188	05212
Ensembl ID		ENSG00000188778	ENSG00000165392
Uniprot IDs		A8KAG8 P13945	Q14191
PDB IDs		2CDW	2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR
Enriched GO Terms of Interacting Partners?
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