WRN and WRNIP1

Number of citations of the paper that reports this interaction (PubMedID 11301316)
17

Data Source:
HPRD (in vitro)

		WRN	WRNIP1
Description		WRN RecQ like helicase	WRN helicase interacting protein 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck Neuron Projection	Chromosome, Telomeric Region Nucleus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity Chromatin Binding Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATP Hydrolysis Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding	DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Brain Development Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organism Aging Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process G-quadruplex DNA Unwinding Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Replicative Senescence T-circle Formation Positive Regulation Of Strand Invasion Protein Localization To Nucleolus	DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Regulation Of DNA Repair Regulation Of DNA-dependent DNA Replication Initiation DNA Duplex Unwinding Innate Immune Response Regulation Of Catalytic Activity
Pathways		Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Chronotype ( 30696823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Daytime sleep phenotypes ( 27126917) Exercise treadmill test traits ( 17903301) Fasting glucose change (long-term) ( 31263163) Intelligence (MTAG) ( 29326435) Lifespan ( 25918517) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Metabolite levels ( 23823483) Morning person ( 30696823)	Plateletcrit ( 32888494)
Interacting Genes		37 interacting genes: ADRB3 ATM ATRX BARD1 BLM BRCA1 C8orf86 CDKN2A FEN1 H2AX HTR5A MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 SUMO1 SUMO2 TERF2 TP53 UBXN8 VCP WRNIP1 XRCC5 XRCC6	15 interacting genes: ABL1 BBS2 ERBB3 FXR1 PCNA PIK3R3 PIN1 POLD1 POLD2 POLD4 RIPK1 TOLLIP TRIM14 UBC WRN
Entrez ID		7486	56897
HPRD ID		05212	10494
Ensembl ID		ENSG00000165392	ENSG00000124535
Uniprot IDs		Q14191	Q96S55
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR	3VHS 3VHT
Enriched GO Terms of Interacting Partners?
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