WRN and VCP

Number of citations of the paper that reports this interaction (PubMedID 15037256)
20

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		WRN	VCP
Description		WRN RecQ like helicase	valosin containing protein
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck Neuron Projection	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Cytoplasmic Stress Granule Protein-containing Complex VCP-NPL4-UFD1 AAA ATPase Complex Secretory Granule Lumen Azurophil Granule Lumen Site Of Double-strand Break Derlin-1 Retrotranslocation Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Ficolin-1-rich Granule Lumen ATPase Complex VCP-NSFL1C Complex
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity Chromatin Binding Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATP Hydrolysis Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding	RNA Binding Protein Binding ATP Binding Lipid Binding ATP Hydrolysis Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity K48-linked Polyubiquitin Modification-dependent Protein Binding MHC Class I Protein Binding Identical Protein Binding ADP Binding Ubiquitin-like Protein Ligase Binding BAT3 Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Brain Development Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organism Aging Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process G-quadruplex DNA Unwinding Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Replicative Senescence T-circle Formation Positive Regulation Of Strand Invasion Protein Localization To Nucleolus	DNA Repair Double-strand Break Repair NADH Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Potential Macroautophagy Protein Ubiquitination Viral Genome Replication Translesion Synthesis Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cellular Response To Heat Stress Granule Disassembly Interstrand Cross-link Repair ERAD Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway ATP Metabolic Process Regulation Of Synapse Organization Mitotic Spindle Disassembly Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Aggresome Assembly ER-associated Misfolded Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Autophagosome Maturation Protein-DNA Covalent Cross-linking Repair Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity Regulation Of Aerobic Respiration Cellular Response To Arsenite Ion Positive Regulation Of Oxidative Phosphorylation Regulation Of Protein Localization To Chromatin Positive Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of ATP Biosynthetic Process
Pathways		Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation RHOH GTPase cycle Aggrephagy Attachment and Entry Attachment and Entry
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Phenethyl Isothiocyanate
Diseases
GWAS		Chronotype ( 30696823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Daytime sleep phenotypes ( 27126917) Exercise treadmill test traits ( 17903301) Fasting glucose change (long-term) ( 31263163) Intelligence (MTAG) ( 29326435) Lifespan ( 25918517) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Metabolite levels ( 23823483) Morning person ( 30696823)	Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		37 interacting genes: ADRB3 ATM ATRX BARD1 BLM BRCA1 C8orf86 CDKN2A FEN1 H2AX HTR5A MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 SUMO1 SUMO2 TERF2 TP53 UBXN8 VCP WRNIP1 XRCC5 XRCC6	96 interacting genes: ABHD17C AMFR ANKRD13A AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BAG5 BRCA1 BRSK2 BUD23 CACNA1C CEP19 CLUAP1 CRMP1 CSTF1 DERL1 DGCR6 DTNB ELAVL1 EPSTI1 ESR1 FAF2 FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LINC01554 LNX1 LZIC MAPK8IP2 METTL17 NDRG1 NF1 NFKBIA NGLY1 NOD2 NPLOC4 NSFL1C NTAQ1 NUB1 OPTN PIK3R3 PLAA PPP1R11 PPP1R3A PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF115 RNF19A RNF8 RPL9 RPS6KA1 SELENOS SH2D2A SIGMAR1 SLC43A3 STUB1 STX5 SUMO4 SVIP TOM1L1 TOMM34 TRIM54 UBASH3A UBC UBE4A UBE4B UBOX5 UBXN10 UBXN11 UBXN2A UBXN2B UBXN4 UBXN6 UBXN7 UFD1 USP7 VAMP2 VCPIP1 VCPKMT WAC WRN XAF1 YOD1 YWHAZ ZBTB25
Entrez ID		7486	7415
HPRD ID		05212	03013
Ensembl ID		ENSG00000165392	ENSG00000165280
Uniprot IDs		Q14191	P55072 V9HW80
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR	3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW 4KDI 4KDL 4KLN 4KO8 4KOD 4P0A 5B6C 5C18 5C19 5C1A 5C1B 5DYG 5DYI 5EPP 5FTJ 5FTK 5FTL 5FTM 5FTN 5GLF 5IFS 5IFW 5KIW 5KIY 5X4L 6G2V 6G2W 6G2X 6G2Y 6G2Z 6G30 6HD0 6MCK 7JY5
Enriched GO Terms of Interacting Partners?
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