WRN and FEN1

Number of citations of the paper that reports this interaction (PubMedID 11598021)
106

Data Source:
HPRD (in vitro, in vivo)

		WRN	FEN1
Description		WRN RecQ like helicase	flap structure-specific endonuclease 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck Neuron Projection	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity Chromatin Binding Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATP Hydrolysis Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Manganese Ion Binding Flap Endonuclease Activity
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Brain Development Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organism Aging Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process G-quadruplex DNA Unwinding Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Replicative Senescence T-circle Formation Positive Regulation Of Strand Invasion Protein Localization To Nucleolus	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair, Gap-filling Double-strand Break Repair Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Positive Regulation Of Sister Chromatid Cohesion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate
Drugs			Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Chronotype ( 30696823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Daytime sleep phenotypes ( 27126917) Exercise treadmill test traits ( 17903301) Fasting glucose change (long-term) ( 31263163) Intelligence (MTAG) ( 29326435) Lifespan ( 25918517) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Metabolite levels ( 23823483) Morning person ( 30696823)	Asthma ( 31959851 31619474) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 28067908) Daytime nap ( 33568662) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hemoglobin levels ( 32327693) Laryngeal squamous cell carcinoma ( 25194280) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483 23378610) Oleic acid (18:1n-9) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 22139419) QT interval ( 29874175) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278) Resting heart rate ( 27798624) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		37 interacting genes: ADRB3 ATM ATRX BARD1 BLM BRCA1 C8orf86 CDKN2A FEN1 H2AX HTR5A MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 SUMO1 SUMO2 TERF2 TP53 UBXN8 VCP WRNIP1 XRCC5 XRCC6	19 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 HUS1 OGT PCNA RAD1 RAD9A TERF1 WDR4 WRN
Entrez ID		7486	2237
HPRD ID		05212	02670
Ensembl ID		ENSG00000165392	ENSG00000168496
Uniprot IDs		Q14191	P39748 Q6FHX6
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR	1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG 6TNZ
Enriched GO Terms of Interacting Partners?
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