ERLIN1 and TMEM199

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ERLIN1	TMEM199
Description		ER lipid raft associated 1	transmembrane protein 199
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Protein-containing Complex	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Cholesterol Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	Cholesterol Metabolic Process Ubiquitin-dependent ERAD Pathway SREBP Signaling Pathway Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process	Cellular Iron Ion Homeostasis Lysosomal Lumen Acidification Cellular Response To Increased Oxygen Levels Vacuolar Proton-transporting V-type ATPase Complex Assembly Lysosomal Protein Catabolic Process
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Osteoprotegerin levels ( 25080503) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: AGR3 BNIP2 FA2H RBFA SEC22A SEC23A TMEM199	17 interacting genes: AQP6 BIK CCR2 CD300A EBP ELOVL4 ERLIN1 IFNGR2 JAGN1 KASH5 LMNA REEP4 SLC10A4 STX1A STX4 TIMMDC1 TMEM14B
Entrez ID		10613	147007
HPRD ID		08502	12679
Ensembl ID		ENSG00000107566	ENSG00000244045
Uniprot IDs		O75477	Q8N511
PDB IDs
Enriched GO Terms of Interacting Partners?
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